Primary lateral sclerosis as a phenotypic manifestation of familial ALS.
نویسندگان
چکیده
Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS from unrelated SOD1-negative familial ALS families. These observations provide further evidence that PLS can be linked pathophysiologically to ALS.
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ورودعنوان ژورنال:
- Neurology
دوره 64 10 شماره
صفحات -
تاریخ انتشار 2005